A small but eye-opening 2022 study in JAMA Psychiatry found that just two doses of psilocybin (along with talk therapy) led to an 83% decline in heavy drinking among participants (who all had alcohol use disorder). Those given a placebo plus talk therapy reduced their alcohol intake by 51%. By the end of the eight-month trial, nearly half of those who received psilocybin had stopped drinking completely, compared with about a quarter of those given the placebo plus talk therapy.
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